the expression of b7-h3 molecule in periodontal disease

نویسندگان

saumya john dept. of periodontics, pushpagiri college of dental sciences, kerala university of health sciences, kerala, india.

arun kurumathur dept. of periodontics & implantology, ragas dental college, tamil nadu dr mgr medical university, tamil nadu, india.

avaneendra talwar dept. of periodontics & implantology, ragas dental college, tamil nadu dr mgr medical university, tamil nadu, india.

keerthana kumar dept. of periodontics & implantology, ragas dental college, tamil nadu dr mgr medical university, tamil nadu, india.

چکیده

statement of the problem: t cells have been shown to play a role in the etiopathogenesis of periodontal disease. b7-h3, a costimulatory molecule, is found to be associated with regulation of t cell function in some tumoral tissues, as well as autoimmune and inflammatory diseases. purpose: the aim of this study was to investigate the expression of b7-h3 molecule in healthy and diseased gingival tissue samples. materials and method: gingival samples were taken from 2 groups (a and b) representing periodontal health and periodontal disease, respectively. these were paraffinized and processed to carry out immunostaining to identify b7-h3 expression. the slides were then examined under light microscope to assess the positive staining in epithelium and connective tissue. the intensity of positive staining in epithelium and the number of positive cells in the connective tissue were evaluated. statistical analysis was done using kappa analysis and independent t-test. results: kappa analysis revealed good inter-examiner agreement for both the groups (group a: 0.718; group b: 0.797). intensity of staining in the epithelium ranged from intense to moderate for both the groups. in the connective tissue, there was a statistically insignificant decrease ( p value= 0.415) in the number of positive cells from group a (mean labeling index: 50.28±26.09) to group b (mean labeling index= 41.37±25.29). conclusion: b7-h3 molecule has been found to be expressed in gingival tissue samples; however, it showed a statistically insignificant decrease in periodontal disease group compared to healthy group.  keywords ● b7-h3  ● periodontitis  ● immunohistochemistry

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Expression of B7-H3 Molecule in Periodontal Disease

STATEMENT OF THE PROBLEM T cells have been shown to play a role in the etiopathogenesis of periodontal disease. B7-H3, a costimulatory molecule, is found to be associated with regulation of T cell function in some tumoral tissues, as well as autoimmune and inflammatory diseases. PURPOSE The aim of this study was to investigate the expression of B7-H3 molecule in healthy and diseased gingival ...

متن کامل

Anterior pituitary progenitor cells express costimulatory molecule 4Ig-B7-H3.

Stem/Progenitor cells in the postnatal pituitary gland are embedded in a marginal cell layer around Rathke's pouch. However, the nature and behavior of anterior pituitary progenitor cells remain unclear. We established bovine anterior pituitary progenitor cell line (BAPC)-1 from the anterior pituitary gland, which expressed stem/progenitor cell-related genes and several inflammatory cytokines. ...

متن کامل

B7-H3: another molecule marker for Mo-DCs?

Using a newly generated monoclonal antibody (2E6) against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes (Mo-DCs). Its expression was examined by means of immunostaining and flow cytometric (FCM) analysis. The results showed that B7-H3 was expressed in the course of Mo-DC maturation induced with interleukin 4 (IL-4) and granulocyte/macrophage c...

متن کامل

B7-H3 protein expression in a murine model of osteosarcoma

Osteosarcoma is an aggressive type of bone tumor that commonly occurs in pediatric age groups. The complete molecular mechanisms behind osteosarcoma formation and progression require elucidation. B7-H3 is a protein of the B7 family that acts as a co-stimulatory molecule with a significant role in adaptive immune responses. The link between B7-H3 expression and its role in different types of can...

متن کامل

B7‐H3 protein expression in acute myeloid leukemia

Costimulatory molecules are essential regulators of the immunological synapse and enable the fine-tuning of the immune response. These mechanisms are subverted by cancer cells to evade immunosurveillance. The B7 family of costimulatory molecules comprises several ligands that may contribute to immunoescape. B7-H3 [B7-homolog 3 or CD276] remains poorly investigated in hematological malignancies....

متن کامل

The co-stimulatory molecule B7-H3 promotes the epithelial-mesenchymal transition in colorectal cancer

B7-H3, first recognized as a co-stimulatory molecule, is abnormally expressed in cancer tissues and is associated with cancer metastasis and a poor prognosis. However, as an initial event of metastasis, the relationship between the Epithelial-Mesenchymal Transition (EMT ) in cancer cells and B7-H3 has still not been investigated. In this study, we first analyzed B7-H3 expression by immunohistoc...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
journal of dentistry, shiraz university of medical sciences

جلد ۱۸، شماره ۱، صفحات ۱-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023